Commensal fungi and their cell‐wall β‐glucans direct differential responses in human intestinal epithelial cells

Intestinal epithelial cells (IECs) are the first to encounter luminal antigens and play an active role in intestinal immune responses. We previously reported that β-glucans, major fungal cell-wall glycans, induced chemokine secretion by IEC lines a Dectin-1- Syk-dependent manner. Here, we show contrast stimulation of with Candida albicans Saccharomyces cerevisiae did not induce any proinflammatory cytokines IL-8, CCL2, CXCL1, GM-CSF. Commensal fungi β-glucans activated Syk ERK lines. However, only p38, JNK, transcription factors NF-κB p65 c-JUN, which were necessary for cytokine secretion. Furthermore, costimulation C. yielded decreased compared alone. Finally, ex vivo human colonic mucosal explants zymosan albicans, leads phosphorylation, implying recognition similar initial signaling pathways as Lack response commensal may reflect IECs’ other than contribute tolerance. Skewed impair homeostasis inflammation.